Neural tube defects (NTDs) are the major targets of prenatal diagnosis, along with down syndrome. Neural tube defects are severe congenital malformations affecting 1 in every 1000 pregnancies and become the second commonest group of birth defects, after congenital heart defects.The improved resolution of ultrasound has reportedly improved the accuracy of NTD diagnosis from ultrasound over amniocentesis in the patients with elevated maternal serum AFP levels. Here we present our three interesting cases of NTDs that verify the necessity of ultrasonography as main instruments on NTDs diagnosis making. Conclusively, proper prenatal diagnosis will leads to better outcome; made under repeated evaluations. Prior consultation to other related department and good counseling would be needed to encompass patient on decision-making, and thus, give chance to undergo a primary prevention. Keywords. Anencephaly, birth defect, myelomeningocele, neural tube defects, prenatal diagnosis, ultrasound.